ITC is a physical technique used to determine the thermodynamic parameters of interactions in solution such as binding affinity (Ka), enthalpy changes (ΔH) and binding stoichiometry. From these initial measurements Gibbs energy changes (ΔG), and entropy changes (ΔS), can be determined. This technique is most often used to study the binding of small molecules (such as medicinal compounds) to larger macromolecules (proteins, DNA etc.).
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